Abstract: Background: Worldviews define reality and stipulate the specific attitudes towards each component of reality. This study assessed how traditional religious worldview in southeast Nigeria has persisted as a driver of healthcare practices in the region. The study was carried out in southeast Nigeria, particularly, Enugu and Anambra States. Data Source and Methods: Data for the study were collected using a six-item questionnaire administered to 400 respondents, and analyzed using simple percentages. Results: Most of the respondents see ailments as curses from gods/deities, or malicious machinations from evil forces. The predominant initial healthcare practice for ailments such as leg ulcer is to go to a dibia (6 I%) or to a faith healing home (29%). Conclusion: For health-interventions to succeed in southeast Nigeria, there is need for pre- intervention campaigns. There is also urgent need to proscribe faith healing homes in the region. Keywords: Traditional Religion, Worldview, Driver, Healthcare, Nigeria